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A new paradigm in breast cancer treatment is emerging. A recent study published in Cell Stem Cell introduces an innovative “Breast Cancer-on-Chip” model for evaluating the efficacy and safety of patient-specific CAR-T cell therapy. This research was conducted by Dr. Tengku Ibrahim Maulana and his team at the University of TĂĽbingen, Germany.
CAR-T cell therapy has shown remarkable success in treating blood cancers but faces significant challenges in solid tumors like breast cancer. To address these challenges, Dr. Maulana and his team developed a “Breast Cancer-on-Chip” model that accurately replicates the 3D microenvironment and vasculature of solid tumors. This model is designed to simulate the administration, recruitment, and infiltration of CAR-T cells, allowing for patient-specific monitoring of efficacy and safety.
The “Breast Cancer-on-Chip” model developed in this study offers several distinct advantages over traditional organ-on-chip models:
This study significantly advances the application potential of CAR-T cell therapy for solid tumors. The “Breast Cancer-on-Chip” model is expected to yield the following benefits:
Dr. Maulana and his team have opened new avenues for CAR-T cell therapy through this study, promising significant contributions to the development of treatments for various solid tumors. This research marks a critical milestone in the future of cancer therapy.
Maulana, Tengku Ibrahim, et al. “Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells.” Cell Stem Cell (2024).
@ 2024 . All rights reserved
@ 2024 . All rights reserved
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